Vitamin D and respiratory disorder
Publish place: Reviews in Clinical Medicine، Vol: 2، Issue: 4
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RCM-2-4_008
تاریخ نمایه سازی: 6 اسفند 1398
Abstract:
The active form of vitamin D is synthesized in some body organs following sun exposure and dietary intake. Vitamin D exhibits its major and critical effects not only through regulation of calcium and phosphate metabolism but also by influencing on respiratory and immune system. Serum concentrations of 25-hydroxyvitamin D below the optimum limit lead to vitamin D insufficiency or maybe deficiency. These inappropriate concentrations of vitamin D lead to different types of pulmonary diseases such as viral and bacterial respiratory infection, asthma, chronic obstructive pulmonary disease, and cancer. In this review we described the association between vitamin D deficiency and severe therapy resistant asthma. We also reviewed the underlying molecular mechanism of vitamin D deficiency in children with severe- therapy resistant asthma. Based on current information, future clinical trial are needed to study the role of vitamin D supplementation on different groups of patients with severe asthma including infants, children of school age, and ethnic minorities.
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Authors
Mahnaz Hushmand
Departments of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh Behmanesh
Departments of Pediatric Asthma and Allergy, Ghaem Hospital,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamid Ahanchian
Departments of Pediatric Asthma and Allergy, Ghaem Hospital,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam Khalesi
Departments of Pediatrics, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
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