HTLV-1: ancient virus, new challenges
Publish place: Reviews in Clinical Medicine، Vol: 1، Issue: 3
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RCM-1-3_009
تاریخ نمایه سازی: 2 دی 1398
Abstract:
Human T-lymphotropic virus (HTLV-1) is an ancient pathogen for human being but arising and recognized recently. The routes of transmission are vertical (mainly by breastfeeding), unsafe sexual contacts and through contaminated blood components specially in whom need frequent and repeated blood transfusions such as permanent anemia due to blood loss in hemophilia and major thalassemia. Patients who should undergo hemodialysis in their lifelong are another instance for increased risk of HTLV-1 exposure. The main HTLV-1-associated diseases are tropical spastic tetraparesis (HAM/TSP), an inflammatory myelopathy and adult T-cell leukemia (ATL). Although HTLV-1 is scattered around the world, only in endemic areas where prevalence rate is more than 1%, viral burden of infection have accumulated. Japan, Southern and Central parts of Africa, Caribbean basin and Iran are examples of endemic areas of HTLV-1. In this article, a rapid and brief review of HTLV-1 virology, immunology and pathogenesis have emerged. In addition, a short debate has driven about current statues of HTLV-1 in Iran.
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Authors
Marzieh Rahimzadegan
Department of Infectious Diseases, Imam Reza Hospital, Mashhad University of Medical Science, Mashhad, Iran.
Farshid Abedi
Department of infectious diseases, Imam reza hospital, Mashhad university of Medical science, Mashhad, Iran.
Seyed Abodolrahim Rezaei
Department of immunology, Ghaem hospital, Mashhad university of Medical science, Mashhad, Iran
Reza Ghadimi
Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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