Evaluation of polyphenolic structures on the β-amyloid aggregates compared with amorphous aggregates in the in-vitro conditions

Background and Aim : The aurone derivatives are a class of polyphenols family, which assumed that could bind to neurofibrillary tangle structures in-vivo in contrast with other probes incapability such as ThT and ThS. Therefore it is required to examine alternative synthetic compounds in-vitro first and then expand the experimental strategy to in-vivo circumstancesMethods : In this study, we inquired five types of synthetic compounds in the two different protein conditions. This examination provided a primary approach of understanding related to polyphenols family to be used instead of traditional probes to detect amyloid fibrils.Results : The turning point of new compounds came from the intrinsic core structure of polyphenols. In other words, it has been imagined that the synthetic compound could cross the blood-brain barrier just against Thioflavin T/S because of their natural featuresConclusion : . According to previously published data related to the mentioned compounds, they contain no positive charge and law lipophilicity coefficient, which has been an obstacle in-vivo studies of Thioflavin T for a long time.

Keywords:

Polyphenol family , Synthetic compounds , Thioflavin T , Blood-brain barrier , Amyloid fibrils