Solanum nigrum enhances pentobarbital-induced sleeping behaviors

Background and Aim : Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of solanum nigrum was studied in mice.Methods : The hydro-alcoholic extract (HAE) and three fractions including water fraction (WF), ethyl acetate fraction (EAF), and n-hexane fraction (NHF) of solanum nigrum were prepared to determine the hypnotic effect of this plants. The mice, were given a single dose of vehicle, diazepam, and extracts and fractions. After 30 minutes, pentobarbital was injected to induce sleep. Then, the hypnotic and toxic effects HAE and fractions were evaluated.Results : According to results, HAE could significantly increase the duration and decreases sleep latency at doses of 50 and 100 mg/Kg. Among the three fractions, only NHF significantly increase the duration of sleep and decreased the sleep latency compared to normal saline.Conclusion : The results suggested that solanum nigrum potentiates pentobarbital hypnosis without causing toxic effects.

Keywords:

Hypnotic , solanum nigrum , Pentobarbital , PC12 , Sleep