The effects of Olibanum on memory impairment induced by Scopolamine in rats
Publish place: 8th basic and clinical neuroscience congress
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NSCMED08_332
تاریخ نمایه سازی: 15 دی 1398
Abstract:
Background and Aim : Olibanum as a resin of Boswellia serrata (B. serrata) from Burseracea family has been proposed as an effective anti-inflammatory and antioxidant agent. We are suggested that this resin can attenuate the generation of oxidant agents and reinforce the anti-oxidant agents to improve memory impairment induced by scopolamine.Methods : Forty male Wistar rats were divided into four groups (n=10 each group): Control (diluted DMSO + saline), Scopolamine (diluted DMSO + 1mg/kg Scopolamine), Scopolamine- Oliban 100 and Scopolamine- Oliban 200 (Olibanum 100 mg/kg or 200 mg/ kg before Scopolamine). Learning and memory performance and biochemistry data were evaluated in all groups.Results : Scopolamine administration increased the duration and distance to find the platform in the Morris water maze(MWM) test in compare to control group in 5 days (P<0.05 to P<0.001) while, scopolamine decreesed the latency to enter to the dark compartment after receiving the sock in passive avoidance (PA) test (P<0.001). Pretreatment with both doses of Olibanum enhanced performances of the rats in MWM (P<0.05 to P<0.01) and PA test (P<0.01 to P<0.001). scopolamine also increased hippocampal MDA levels (P<0.001) while, decreased CAT, SOD and thiol (P<0.001). Olibanum increased hippocampal CAT, SOD and thiols (P<0.01 to P<0.001).Conclusion : Olibanum showed an anti-inflammatory and antioxidant properties. It could improve memory impairment induced by scopolamine.
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Authors
Narges Marefati
Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Iran
Mahmoud Hosseini
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran