Effect of Platelet Lysate on Wound/Ulcer Healing and Tissue Repair

Wound and ulcer healing are one of the major clinical problems with a great impact on personal, professional and social levels of individuals with high treatment costs. According to available treatments, there are still no definitive and sufficient therapies for chronic wounds. Physiologically, platelets localize in wound or ulcer site and stimulate cell migration, wound healing and tissue repair by secreting growth factors and cytokines after injury. Recently, hemoderivative materials such as platelet-rich plasma, platelet-rich fibrin, and platelet gel are used to treat wounds. Platelet lysate is a novel hemoderivative material which is used for tissue repair. It contains more platelet-derived growth factors compared to the other hemoderivative materials. Additionally, unlike the other hemoderivative material, this product contains no platelet membranes and leukocytes and can be stored at -20 ° C or lower for a long time. Platelet lysate have been used for wounds healing alone or in combination with a variety of bioactive scaffolds and bioactive dresses such as fibrin-based scaffold and Collagen/Gelatin Scaffold. Growth factors such as platelet-derived growth factor, vascular endothelial growth factor, and fibroblast growth factor cause angiogenesis, migration and proliferation of epithelial cells and fibroblasts, extracellular matrix remodeling, nerve repair, reduce inflammation and consequently wound healing and tissue repair. Platelet lysates with high growth factor levels are a suitable material for wound healing and nerve tissue repair; however, this product should be used with caution to prevent the possible risk of abnormal proliferation at the wound site due to high amount of growth factors.

Keywords:

Platelet Lysate , Wound Healing , Ulcer Healing , Tissue Repair , Regenerative medicine