TLR2 and TLR4 Genes Expression Analysis : A Hopeful Approach To Recognition Causes of Essential Hypertension

Background: Cardiovascular diseases (CVD) refer to a group of life threating disorders that affect heart and circulatory system. As a main risk factor, essential hypertension is the most common cause of damages. Previous studies showed different pathways contribute to pathogenesis of hypertension. Among them, inflammatory pathways, particularly immune receptors, due to their important role, need more attention to research. In the other hand, the exact cause of hypertension is not clear, Therefore, in this study we aimed to evaluate TLR2 and TLR4 genes expression in primary hypertensive patients compared with healthy controls.Methods: 50 hypertensive patients and 50 healthy controls (35-65 years old) without any drug consumption and inflammatory disorders participated in this study. peripheral blood obtained and TLR2 and TLR4 genes expression measured by Real-time PCR.Results: TLR2 gene expression up regulated in 36% of patients compared with healthy controls but it was not statistically significant. About TLR4, statistically significant up regulation was observed (P< 0.001).Discussion: Up regulation of innate immunity receptors indicates undeniable role of this pathway in pathogenesis of hypertension and CVD. Our findings suggest that, these pathways can be a suitable candidate for control and treatment of hypertension.

Keywords:

Essential Hypertension , TLR2 , TLR4 , Inflammation