Comparative studies of extraction chromatography and electro-amalgamation separation to produce no-carrier added 177Lu by Tehran research reactor

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IRJNM-25-1_004

تاریخ نمایه سازی: 21 بهمن 1398

Abstract:

Introduction:Owing to its favorable radionuclidic characteristics, such as tl/2 = 6.73 day and Eβ (max) = 497 keV and ease of its large-scale production using medium flux research reactors, lutetium-177 (177Lu) is an attractive radionuclide for various therapeutic applications. No carrier added (NCA) 177Lu was obtained by thermal neutron bombardment (4×1013n/cm2.s) of 176Yb target through 176Yb(n, γ)177Yb        177Lu process have the advantage of preparing radiopharmaceuticals with high specific activity. So the existence of an effective Lu/Yb separation method is critical. Methods: Many researchers illustrated no-carrier added 177Lu production. However, the present study is based on comparison between two potential separation methods, namely extraction chromatography and electro-amalgamation separation with respect to separation yield and radiochemical characteristics. Results: The no carrier added 177Lu separated from 176Yb target by two extraction chromatography and electro-amalgamation separation methods. The effective parameters on separation Lu/Yb were investigated in two procedures. The 177Lu production yield by extraction chromatography and electro-amalgamation procedures were 82% and 88.83% respectively. The no carrier added 177Lu was obtained with radionuclidic purity of 99.99%   in two separation methods. Conclusion: Although both separation methods have exhibited promising feature, the study reveals that electro-amalgamation separation offers the advantages of higher yield of 177Lu, simplicity and easier to operate for large amount of target and less overall processing time.

Authors

Nafise Salek

Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

Mojtaba Shamsaei

Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

Mohammad Ghannadi Maragheh

Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

Simindokht Shirvani Arani

Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

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  • Koppe MJ, Bleichrodt RP, Soede AC, Verhofstad AA, Goldenberg DM, ...
  • Brouwers AH, van Eerd JE, Frielink C, Oosterwijk E, Oyen ...
  • Dash A, Pillai MR, Knapp FF Jr. Production of (177)Lu ...
  • Banerjee S, Das T, Chakraborty S, Venkatesh M. Emergence and ...
  • Pommé S, Paepen J, Altzitzoglou T, Van Ammel R, Yeltepe ...
  • Firestone R, Shirely VS, eds. Table of isotopes. 8th ed. ...
  • Das T, Chakraborty S, Unni PR, Banerjee S, Samuel G, ...
  • Lashko AP, Lashko TN. The study of 177mLu decay. Probl ...
  • Dvorkov Z: Production and chemical processing of 177Lu for nuclear ...
  • Mirzadeh S, Du M, Beets AL, Knapp Jr FF. Method ...
  • Haettner E, Iwase H, Schardt D. Experimental fragmentation studies with ...
  • Choppin GR, Silva RJ. Separation of the lanthanides by ion ...
  • Marhol M. Ion exchangers in analytical chemistry: Their properties and ...
  • Starý J. Separation of transplutonium elements. Talanta. 1966 Mar;13(3):421-437. ...
  • Denzler FO, Lebedev NA, Novgorodov AF, Rosch F, Qaim SM. ...
  • Marx S, Harfensteller M, Zhernosekov K, Nikula T. Method of ...
  • Balasubramanian PS. Separation of carrier-free lutetium-177 from neutron irradiated natural ...
  • Hashimoto K, Matsuoka H, Uchida S. Production of no-carrier-added 177Lu ...
  • Lahiri S, Nayak D, Nandy M, Das NR. Separation of ...
  • Kumrić K, Trtić-Petrović T, Koumarianou E, Archimandritis S, Čomor JJ. ...
  • Watanabe S, Hashimoto K, Watanabe S, Iida Y, Hanaoka H, ...
  • Knapp Jr FR, Mirzadeh S, Beets AL, Du M. Production ...
  • Horwitz EP, McAlister DR, Bond AH, Barrans RE, Williamson JM. ...
  • So LV, Morcos N, Zaw M, Pellegrini P, Greguric I. ...
  • So LV, Morcos N, Zaw M, Pellegrini P, Greguric I, ...
  • Monroy-Guzman F, Barreiro FJ, Salinas EJ, Treviño ALV. Radiolanthanides device ...
  • Lebedev NA, Novgorodov AF, Misiak R, Brockmann J, Rösch F. ...
  • Bilewicz A, Żuchowska K, Bartoś B. Separation of Yb as ...
  • Chakravarty R, Das T, Dash A, Venkatesh M. An electro-amalgamation ...
  • Cieszykowska I, Zóltowska M, Mielcarski M. Separation of Ytterbium from ...
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