Trend of Antibiotic Resistance Among Acinetobacter spp. Strains Isolated From Wound Infections in Ghaem University Hospital in Northeast of Iran From 2005 to 2011

Background: Acinetobacter has become an important cause of different infections such as wound infection, due to its great ability tosurvive and spread in hospital settings and to develop resistance against many antibiotics. Objectives: The aim of this study was to investigate the antibiotic resistance among isolates of Acinetobacter from wound infectionsduring a 7-year period, from 2005 to 2011, in Ghaem University Hospital, Mashhad. Patients and Methods: During this period, patients with nosocomial wound infections were identified according to national nosocomialinfections surveillance system (NNIS) and appropriate samples were taken from their wounds. Furthermore, microbiological procedureswere performed to identify the bacterial strains causing the infection. Antibiotic susceptibility of Acinetobacter isolates was determined bydisk diffusion method. Results: Based on the guideline, 324 cases of infection were identified and 43 samples of Acinetobacter strains were isolated. Duringthis 7-year period, the resistance to kanamycin and norfloxacin was increased among these 43 samples. However, the resistance againstampicillin, ciprofloxacin, cefexime, trimethoprim-sulfamethoxazole, cefotaxime, cefazolin, gentamicin, and ceftizoxime was notsignificantly increased. The overall bacterial resistance was high. The pick of Acinetobacter species was observed in 2006 and 2007. Conclusions: Our results demonstrated a high antibiotic resistance among Acinetobacter species isolated from wound infections. Theincreased resistance to antibiotics such as kanamycin and norfloxacin was due to their vast application in treatments. Moreover, thedecreased resistance to other noted antibiotics was probably due to their low application.

Trend of Antibiotic Resistance Among Acinetobacter spp. Strains Isolated From Wound Infections in Ghaem University Hospital in Northeast of Iran From 2005 to 2011 Keywords:

Acinetobacter , Drug Resistance , Microbial , Wound Infection