Efficacy of Simultaneous Usage of Bevacizumab and Silicone Oil Injection After Vitrectomy in Diabetic Tractional Retinal Detachment

Background: Tractional retinal detachment (TRD), a major vision threatening complication, is one of the most common eye emergencies.The most common cause of TRD is proliferative diabetic retinopathy (PDR). The aim of this study was to evaluate the effectof simultaneous usage of bevacizumab and silicone oil injection after vitrectomy for the treatment of diabetic tractional retinaldetachmentMethods: Twenty five patients (25 eyes) with severe proliferative diabetic retinopathy were recruited into the study. All eyes underwenta single intravitreal injection of bevacizumab 1.25 mg in 0.05 mL along with silicone oil injection after vitrectomy for themanagement of tractional retinal detachment or vitreous hemorrhage due to severe proliferative diabetic retinopathy. Patientswere then scheduled for postoperative clinical examinations at one, three and six months. The main outcome measures were regressionof neovascularization, intraocular pressure, visual acuity and retinal reattachment.Results: This study evaluated 25 eyes of 25 patients (12 men, 13 women) with a mean age of 55.68 6.94 years (range 21 to 49 years).In all eyes visual acuity improved and retinal attachment was accomplished. The mean preoperative visual acuity was 2.01 0.03Log MAR which significantly improved to 1.10 0.50 Log MAR in 6th month after surgery (P < 0.000). Active neovascularizationregressed significantly (P < 0.004) and intraocular pressure was controlled in 88% of patients.Conclusions: The findings of our study may suggest that simultaneous injection of Bevacizumab and silicone oil after vitrectomyimprove early results. We have found it to be particularly useful in diabetic eyes with tractional detachments of short duration.

Efficacy of Simultaneous Usage of Bevacizumab and Silicone Oil Injection After Vitrectomy in Diabetic Tractional Retinal Detachment Keywords:

Tractional Retinal Detachment , Proliferative Diabetic Retinopathy , Neovascularization , Vascular Endothelial GrowthFactor , Vitreous Hemorrhage , Avastin