In this paper, the vibrational and buckling analysis of a cylindrical sandwich panel with an elastic core under thermo-mechanical loadings is investigated. The modeled cylindrical sandwich panel as well as its equations of motions and boundary conditions is derived by Hamilton’s principle and the first-order shear deformation theory (FSDT). For the first time in the present study, various boundary conditions is considered in the cylindrical sandwich panel with an elastic core. In order to obtain the temperature distribution in the cylindrical sandwich panel in the absence of a heat-generation source, temperature distribution is obtained by solving the steady-state heat-transfer equation. The accuracy of the presented model is verified using previous studies and the results obtained by the Navier analytical method. The novelty of the present study is considering thermo-mechanical loadings as well as satisfying various boundary conditions. The generalized differential quadrature method (GDQM) is applied to discretize the equations of motion. Then, some factors such as the influence of length-to-radius ratio, circumferential wave numbers, thermal loadings, and boundary conditions are examined on the dynamic and static behavior of the cylindrical sandwich panel.