Reno–Protective Effects of VitaminB12 on Aminoglycosides induced nephrotoxicity in rat
Publish place: The 19th Annual Congress of Medical Students of Iran
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
View: 567
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
AMSMED19_123
تاریخ نمایه سازی: 1 دی 1397
Abstract:
Background and Objective: Aminoglycosides are one of the common causes of drug-induced nephrotoxicity. The antioxidant, anti-inflammatory effect of Vitamin B12 was investigated on gentamicin nephrotoxicity in rats. Materials and Methods: Renal injury induced by i.p.injection of gentamicin (100 mg/kg) for 8 consecutive days. (6 mg/kg/day, i.p) treatment was done for 8 consecutive days as co-treatment and post-treatment protocol. Findings: Vitamin B12 significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid per oxidation and ameliorated renal tissue damage mediated by gentamicin. Conclusion: The results of the current study indicated VitaminB12 that effectively protected the kidney tissue against gentamicin induced acute nephrotoxicity in rats and increased anti-inflammatory defense.
Keywords:
Authors
Zeinab Hamidizad
Arak University of Medical Sciences, Arak, Iran.
Saeed Hajihashemi
Arak University of Medical Sciences, Arak, Iran.
Ali Rahbari
Arak University of Medical Sciences, Arak, Iran.
Leila Ghanbari
Arak University of Medical Sciences, Arak, Iran.