COI code: INC15_083
Paper Language: English
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Authors CIRCULATING OMENTIN-1 MIGHT BE ASSOCIATED WITH METABOLIC HEALTH STATUS IN DIFFERENT PHENOTYPES OF BODY SIZEShahab Alizadeh - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Abstract:Background and Aim: Adipokines are mediators of body composition and are involved in obesity complications.This study aimed to assess the association of circulating omentin-1, vaspin, and RBP-4 with bodycomposition indices and metabolic health status (MHS) in different phenotypes of body size.Methods: A total of 350 subjects were included in the current cross-sectional study.Body composition was measured using a body composition analyzer, and serum concentrations of omentin-1, vaspin, and RBP-4 were assessed by ELISA kits. Results: Circulating omentin-1 was significantly (OR = 1.81, 95% CI: 1.00-1.91, P = 0.01) and marginally (OR = 1.63, 95%CI: 1.00-1.75, P =0.06) associated with MHS in the overweight and obese subjects, respectively. But no association was seen between omentin-1 and MHS in normal-weight subjects. Serum levels of vaspin and RBP-4 were not correlated with MHS. Furthermore, a significant positive correlation was observed between circulating omentin-1 and body mass index (BMI) as well as fat percentage (P = 0.02) in the MHS group. Serum vaspin concentrations were not related to body composition components in both groups. In addition, in the MHS group, circulating RBP-4 was positively correlated with fat percentage and fat mass (FM) (p < 0.0001) and was negatively correlated with fat-free mass (FFM) and total body water (TBW) (p < 0.0001). In contrast, in the metabolically unhealthy group, RBP-4 was negatively correlated with fat percentage, FM, and BMI (p < 0.0001) and was positively correlated with FFM and TBW (p<0.0001).Conclusion: This study showed that circulating levels of omentin-1 are useful predictors of metabolic health status in overweight and obese people.
Keywords:Omentin-1; vaspin; RBP-4; obesity; body composition
COI code: INC15_083
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Alizadeh, Shahab, 2018, CIRCULATING OMENTIN-1 MIGHT BE ASSOCIATED WITH METABOLIC HEALTH STATUS IN DIFFERENT PHENOTYPES OF BODY SIZE, Third International Congress and Fifteenth Iranian Nutrition Congress, تهران, دانشگاه علوم پزشكي شهيد بهشتي - انجمن تغذيه ايران،انستيتو تحقيقات تغذيه اي و صنايع غذايي كشور،انجمن علمي تغذيه ايران, https://www.civilica.com/Paper-INC15-INC15_083.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Alizadeh, Shahab, 2018)
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Type: Medical University
Paper No.: 6412
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