Effect of curcumin on sperm parameters invitro and invivo

Background: Reactive oxygen species (ROS) generation, induced by the cryopreservation process, can be responsible for mammalian sperm damage. Curcumin is known as an effective antioxidant against oxidative stress. In this article we investigated the effects of curcumin treatment on sperm quality parameters in vitro and invivo Methods: This article was a systematic review article. Result: Some articles suggested that the effects of curcumin were dependent on its concentration. in male germ cells in vivo the protective effect was seen despite the low bioavailability of curcumin. In contrast, high, unattainable in the organism, concentration of curcumin had a cytotoxic effect on male reproductive cells in vitro. Based on some results, it is concluded that curcumin addition during freezing resulted in positive effects on sperm parameters such as motility, morphology and DNA integrity after thawing in adult rats.Conclusion: The results suggest that curcumin may have a protective role against oxidative damage in male reproductive system.

Keywords:

curcumin , invitro , invivo , sperm