Report a case of Crimean-Congo fever with hemophagocytosis syndrome

The pathogenesis of Crimean-Congo hematologic fever (CCHF) is complex and multifactorial. Most patients die from bleeding due to DIC, thrombocytopenia and endothelial damage to the vessels. Endothelial damage to the vessels caused by direct invasion of the virus or cytokine cascade initiated by immunological mechanisms. Apparently, it plays an important role in this pathogenesis. It seems that the cytokine cascade occurs the predominantly in hemophagocytosis syndrome. Considering this issue and early diagnosis of hemophagocytosis syndrome in severe clinical cases of CCHF can change the treatment approach from prescribing only antiviral drugs and preservatives to conventional treatments for hemophagocytosis syndrome. Perhaps for the early diagnosis of this issue, the level of serum ferritin in patients is a strong indicator. However, more studies are needed to determine this issue and the selective treatment of Hemophagocytosis syndrome caused by CCHF.

Keywords:

Crimean-Congo Hematologic Fever , hemophagocytosis syndrome , Ferritin