Biodistribution of [64Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex in fibrosarcoma-bearing rats [Persian]

Introduction: 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM) is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling with 64Cu-actetate. The tracer was finally administered to fibrosarcoma-bearing rats and the biodistribution was determined in critical tissues as well as tumor. Results: The final radiopharmaceutical solution underwent common quality control tests for animal injection a radiochemical purity > 95% was determined. A significant tracer tumor uptake was observed 2 hours post injection. Tumor:muscle and tumor:blood ratios were shown to be 8 and 6 respectively. Conclusion: 64Cu-PTSM prepared in this report is a good candidate for tumor therapy as well as diagnosis for national use.

Keywords:

Radiopharmaceuticals , PET , Fibrosarcoma , Copper-64 , 64Cu-PTSM