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Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]

Publish Year: 1384
Type: Journal paper
Language: English
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JR_IRJNM-13-1_005

Index date: 15 April 2020

Preparation of [111In]-Bleomycin radiopharmaceutical [Persian] abstract

In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final sample was injected into fibrosarcoma-bearing mice via their tail vein. Satisfactory preliminary SPECT images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.

Preparation of [111In]-Bleomycin radiopharmaceutical [Persian] Keywords:

Preparation of [111In]-Bleomycin radiopharmaceutical [Persian] authors

Amir Reza Jalilian

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran

Mohammad Mirzaie

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran

Alireza Karimian

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran

Jamshid Moafian

Cyclotron and Nuclear Medicine Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran