Biosynthesis of magnetic core-shell magnetic MOF/Ag nanocomposites for drug delivery in cancer therapy

Porous metal organic frameworks (MOFs) with greater tunability and high surface area may be more suitable for the drug delivery applications. A facile and efficient strategy is proposed to prepare Ag-nanoparticle-embedded magnetic metal−organic frameworks [Fe3O4@MIL-100 (Fe)/Ag]. Facile synthesis of core-shell magnetic MOFs for drug delivery is of significance due to the advantages of high drug load and easy separation. For synthesis of Fe3O4 nanoparticle and Ag nanoparticle were used by natural reagents, as one reducing and capping agent. The as-prepared nanocomposites are regular spherical and contain a Fe3O4 core with an average diameter of 25 nm, which make them exhibit goodmagnetic properties and can be conveniently separated. A 40 nm MIL- 100(Fe) MOF shell is uniformly coated on the Fe3O4 core and loads well-dispersed 12 nm Ag nanoparticles in their pores, which make the nanocomposites have excellent potential drug delivery for cancer therapy. The composite were characterized by technique like FT-IR, XRD and FE-SEM to understand the effect of the nanoparticle in MOF structure. The cytotoxicity of Fe3O4@MIL-100 (Fe)/Ag NPs was verified against K562 cells lines.The cytotoxicity assay showed that the magnetic MOFs have low cytotoxicity and good biocompatibility. The resulted bio-nanocomposite showed that this carrier system could be potentially used in anticancer drug delivery systems

Keywords:

biosynthesis , magnetic core-shell , Ag nanoparticles , Fe3O4 nanoparticles , drugdelivery , magnetic MOF