Ochronosis, the Rare Cause of Herniation of a Disc: A Case Report
Publish place: Iranian Journal of Neurosurgery، Vol: 5، Issue: 3
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
View: 230
This Paper With 6 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJN-5-3_010
تاریخ نمایه سازی: 20 دی 1399
Abstract:
Background and Importance: Alkaptonuria is a rare genetic disorder due to homogentisic acid oxidase deficiency which eventuates in the reposition of homogentisic acid in different parts of the body and multi-organ involvements. The characteristic bluish-black discoloration of the skin and cartilage tissue is known as ochronosis.
Case Presentation: Herein, we reported a 45-year-old woman with chronic pain in the lumbar area and radicular pain in her left leg, aggravating gradually during the previous six months before the operation. She also suffered from progressive muscle weakness in her left lower extremity. The
patient was operated for prolapsed disc herniation. Macroscopically, no abnormality of the skin, muscles, or ligaments was observed during surgery. After incision of the annulus in level L3-L4, surprisingly the excised nucleus pulposus was black. The alkaptonuria was diagnosed after histopathological examination of the black disc material and confirmed by urinalysis.
Conclusion: The postoperative course was uneventful and the patient was free from low back pain and leg pain after surgery. In patients without any manifestations of alkaptonuria or ochronosis such as our case, timely diagnosis of this pathologic condition is momentous for investigation, treatment, and prevention of other organs’ involvement.
Keywords:
Authors
Ali Baradaran Bagheri
Department of Neurosurgery, Alborz University of Medical Sciences, Karaj, Iran
Farsad Biglari
Department of Orthopedics, Alborz University of Medical Sciences, Karaj, Iran
Somayeh Soroureddin
Department of Internal Medicine, Alborz University of Medical Sciences, Karaj, Iran
Salman Azarsina
Department of Orthopedics, Alborz University of Medical Sciences, Karaj, Iran
Mohammad Kamangar
Department of Neurosurgery, Alborz University of Medical Sciences, Karaj, Iran