Association Between IFN-γ +874 T/A (Rs2430561) Polymorphisms and Bipolar 1 Disorder: A Study in an Ethnic Iranian Population

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_RBMB-8-1_001

تاریخ نمایه سازی: 22 دی 1399

Abstract:

Background: The pathophysiology of bipolar 1 disorder (B1D), a major psychiatric disorder with inflammatory origins and structural changes in the brain, is of great interest to researchers. Pro-inflammatory biomarkers and specific gene expression play pivotal roles in B1D development, and IFN-γ has emerged as an important inflammatory marker. The aim of this research was to determine whether the INF-γ +874 T/A polymorphism is associated with B1D susceptibility in an ethnic Iranian population. Methods: The IFN-γ +874 T/A (rs2430561) gene polymorphism was studied in 106 B1D patients and 109 control subjects using sequence specific primers (SSPs) and amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Results: Significant statistical differences in IFN-γ +874 T/A polymorphism genotype distribution were found between the patients and control subjects (P = 0.0006). Decreased risk of B1D was detected in the codominant model (T/T vs T/A and A/A, OR = 0.19, 95% CI = 0.07-0.49 for T/A, OR = 0.38, 95% CI = 0.12-1.24 for A/A, P value=0.0006), and in the dominant model (T/T vs T/A-A/A, OR = 0.21, 95% CI = 0.08-0.54, P = 0.0005). However, no significant difference in the IFN-γ polymorphism allele distribution was found between the two groups (P = 0.25). Conclusions: The IFN-γ +874 T/A polymorphism may have a significant role in BID development.  

Authors

Mahdieh Fatemi Nayeri

Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Ali Talaei

Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Jalil Tavakkol Afshari

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Amin Reza Nikpoor

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Andisheh Talaei

Department of Biotechnology, University College of Science, University of Tehran, Tehran, Iran.

Rashin Ganjali

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.