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Title

The Effect of Vitamin D on Cellular Pathways of Diabetic Nephropathy

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 7، شماره: 2
Year: 1397
COI: JR_RBMB-7-2_014
Language: EnglishView: 112
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Authors

Hoda Derakhshanian - Department of Biochemistry, Genetics and Nutrition, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. & Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Abolghassem Djazayery - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Hassan Javanbakht - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza Eshraghian - Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abbas Mirshafiey - Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mahnaz Zarei - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Ehsan Alvandi - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Ehsan Djalali - Department of Veterinary, Science and Research Branch of Islamic Azad University, Tehran, Iran.
Mahmoud Djalali - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Abstract:

Background: Diabetic nephropathy is one of the most important microvascular complications and a major cause of morbidity and mortality in diabetic patients. This study was designed to investigate the effect of vitamin D on the expression of three key genes involved in the development of diabetic nephropathy. Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups. The first group served as control and the other two groups received intraperitoneal injections of 45 mg/kg STZ to develop diabetes. The groups were treated for four weeks either with placebo or two vitamin D injections of 20,000 IU/kg. Serum glucose, insulin, and HbA1c levels, and AGE cellular receptor (RAGE), aldose reductase (AR) and glutamine: fructose-6-phosphate aminotransferase (GFAT) gene expression were assessed in kidney tissue at the end of the experiment. Results: Vitamin D treatment resulted in a significant increase in insulin concentration, which could improve hyperglycaemia in diabetic rats. Serum HbA1c decreased slightly but insignificantly following the vitamin D injections. In addition, expression of GFAT, a key regulatory enzyme in the hexosamine pathway, was significantly reduced following vitamin D administration. Conclusions: Vitamin D may reduce diabetic nephropathy not only by improving blood glucose and insulin levels, but also by modulating hexosamine pathways in kidney.

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This Paper COI Code is JR_RBMB-7-2_014. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141966/

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Derakhshanian, Hoda and Djazayery, Abolghassem and Javanbakht, Mohammad Hassan and Eshraghian, Mohammad Reza and Mirshafiey, Abbas and Zarei, Mahnaz and Alvandi, Ehsan and Djalali, Ehsan and Djalali, Mahmoud,1397,The Effect of Vitamin D on Cellular Pathways of Diabetic Nephropathy,https://civilica.com/doc/1141966

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Type of center: علوم پزشکی
Paper count: 970
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