The Relationship between Triglyceride level – HDL Level – Tumor Necrosis  Factor and its Soluble Receptors with Lupus Erythematosus Activity

Publish Year: 1384
نوع سند: مقاله ژورنالی
زبان: English
View: 183

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_ZUMS-14-54_001

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background & Objective: Systemic lupus erythematosus (SLE) is a disease with life-threatening complications. Since evidence indicates that measurement of triglyceride (TG) and HDL levels and tumor necrosis α factor (TNF- α) and its types I and II soluble receptors plays a major role in evaluation of lupus activity, this study was conducted to investigate the relationship between the above mentioned factors and lupus activity in Tehran in ۲۰۰۵. Materials & Methods: In this cross-sectional study fasting blood samples were obtained from ۸۶ SLE patients who had been entered into the study through convenient sampling and the disease activity was calculated using the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]. Scores ≥ ۶ were considered as active lupus and <۶ as dormant lupus. Serum levels of TNF- α, sTNFR۱ and sTNFR۲ were measured through ELISA (Bender Medsystem) and blood TG and HDL through routine biochemical tests within ۱۲ hours overnight fasting. The results were analysed by t-test, Mann-Whitney and Pearson correlation tests. Results: ۴۶ people (۵۳.۵%) suffered from dormant disease and ۴۰ people (۴۶.۵%) from active disease. TG level had significant relationship with disease activity, sTNFR۲ (P=۰.۰۰۱) and TNF-α (P=۰/۰۱), while HDL level had inverse significant relationship with SLEDAI (P=۰.۰۰۷), TNF (P=۰.۰۱), STNFR۱ (P=۰.۰۰۱). There was no significant relation between TG and HDL with STNFR۲. Multiple linear analysis of regression showed that three variables (TG, sTNFR۱ and sTNFR۲) are maintained in the model for prognosis of the disease while TNF-α and HDL are omitted. Conclusion: Dislipoproteinemia (elevated TG and reduced HDL) correlates with SLE activity following an increase in TNF-α and its soluble receptors. Thus, serum levels of TG, HDL and TNF-α and its soluble receptors are connected with lupus activity and are valuable markers for the disease activity.

Keywords:

Systemic lupus Erythematosus (SLE) , Triglyceride , HDL , Tumor Necrosis  Factor (TNF-) Soluble receptors of tumor necrosis α factor (sTNFR۱ , sTNFR۲) , Lupus activity index