The Association Between Hyperemesis Gravidarum (HG) and Helicobacter Pylori (H.pylori) Infection.

Background and Objective: HG is a severe form of expectancy nausea and vomiting, occurring in ۰/۵ to ۲% of the expectancies. The etiology of HG is unknown, though hormonal stimuli, and psychologic predisposition are attributable to the condition. Recent studies suggest a relationship between HG and H.pylori infection. The aim of this study was to investigate the  relationship between HG and H.pylori infection. Material and Methods: Forty pregnant women with HG (Treatment group) and forty asymptomatic pregnant women (control group) were assigned into the research from April  to August ۲۰۰۶. Specific serum immunoglobulin G (IgG) for H.pylori was assayed by ELISA. The data was analyzed using SPSS software, Chi-Square and T-test. Results: Out of ۴۰ pregnant women with HG ۲۵ individuals (۶۲/۵%) were found to have serologically positive H.pylori, whereas in asymptomatic pregnant women ۱۹ (۴۷.۵%) individuals were positive, which shows no significant difference between H.Pylori infection with HG (P=۰.۱۷۸). No significant difference was observed between positive H.pylori and the number of pregnancy, body mass index (BMI), and duration of  hospital stay. Conclusion: Since HG has a multifactorial etiology and with regard to high prevalenve of H pylori in our country, research studies with higher sample sizes and utilization of more sensitive diagnostic methods for the detection of active H pylori is recommended.

Keywords:

Hyperemesis gravidrum , Helicobacter pylori , Zanjan