In vitro Antimicrobial Drug-Resistance of Urinary Tract Pathogens in Patients Admitted to Vali-e-Asr Hospital Wards

Background and Objective: Extensive use of antibiotics in medicine has led to resistance of microorganisms in urinary tract infection (UTI) in both children and adults. Therefore, conducting studies on antibiotic susceptibility is needed for selection of antibiotics based on regional studies. Materials and Methods: During the year ۲۰۰۶ urine samples from all symptomatic patients admitted to neonatal, pediatrics, obstetric and neurologic wards were collected through midstream clean-catch, catheterization, or urine bags. An antibiogram test was performed for all ۱۱۸ urine samples which were culture positive. Results: The most common organisms found in neonatal urine culture were klebsiella pneumonia (۴۴/۵%) followed by Escherichia coli (۳۳/۵%). Escherichia coli was the most common organism in pediatrics (۴۱%), obstetric (۴۶%), and neurologic wards (۷۳%). Resistance to ampicillin (۸۲/۶%) and cefixim (۷۳/۶%) was significant in all samples. Ciprofloxacine was the most effective drug against E.coli and klebsiella pneumonia in all wards (resistance rate: ۲۴/۱%) followed by nitrofurantion (resistance rate: ۴۱/۴%), ceftriaxone (resistance rate: ۴۴/۸%) and amikacin (resistance rate: ۵۱/۹%). Vancomycine was the most effective drug against staphylococcus epidermidis (resistance rate: ۳۷/۱%) followed by cephtasidim (resistance rate: ۴۰/۱%) and ciprofloxacine (resistance rate: ۴۸/۵%). Conclusion: Unfortunately due to irrational use of antibiotics, high resistance to ampicillin, cefixim, gentamycin, cotrimoxazol, and some other drugs was observed. Continuous studies regarding the drug resistance are recommended for better assessment in the future.

Keywords:

Drug resistance , Antibiogram , Antibiotic , Urinary traet infection