Comparison of FEV۱ and PEF Values in Cough Variant Asthma During Methacholine Challenge Test
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
View: 251
This Paper With 9 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ZUMS-19-77_003
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background and Objective: Asthma is one of the most common chronic diseases with an increasing prevalence. The cough variant of asthma (CVA) is a latent form of the disease. The aim of this study is to compare the decreasing rates of FEV۱ and PEF during the methacholine challenge test.
Materials and Methods: In this study, we tested a total of ۱۲۰ patients (۱۴-۶۵ years old), whom were referred to the respiratory clinic with complaints of chronic cough, using normal chest and sinus x-ray and spirometry. Also other causes of chronic cough were rulled out. Spirometry and Peak Flowmetry were done during the methacholine challenge test, then FEV۱ and PEF were recorded.
Results: From ۱۲۰ patients, ۴۷ patients (۳۹.۲%) were male and ۷۳ (۶۰.۸%) were female. Thirty three (۲۷.۵%) patients showed a ≥ ۲۰% decrease in FEV۱, while ۳۵ patients (۲۹.۲%) had a ≥ ۲۰% decrease in PEFp. Decreasing values of FEV۱ and PEFp with r=۰.۴۹ and P-value<۰.۰۰۰۱ were significant. Normalization for age, sex, and occupation shows that these factors have no effects on the decrease observed for FEV۱ and PEFp.
Conclusion: Based on the correlation ratio for PEFp in comparison with spirometry’s FEV۱, we suggest using peak flowmetry instead of spirometry for diagnosing CVA. According on the ROC_curve, we recommend a ≥ ۱۵.۵% decrease in the level of PEFp with ۷۹% sensitivity and ۶۹% specificity.
Keywords:
Authors
صمد قدرتی
Dept. of Internal Medicin, Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
احمد حرمتی
Dept. of Internal Medicine,Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
سید نورالدین موسوی نسب
Dept. of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
محبوبه عفیفیان
Tehran University of Medical Sciences, Tehran, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :