The Effect of Elaeagnus Angustifolia Water Extract on Scopolamine-Induced Memory Impairment in Rats

Background and Objective: Impaired cognitive function and memory, a characteristic of Alzheimerchr('۳۹')s disease, can be caused by decreased activity of the cholinergic system. Scopolamine, a muscarinic receptor antagonist, may cause temporary impairment in memory and provide an Alzheimerchr('۳۹')s disease model. This study was designed to evaluate the effects of water extract of Elaeagnus Angustifolia on memory impairment caused by scopolamine. Materials and Methods: ۶۰ male Wistar rats were randomly assigned to ۶ groups (n=۱۰ for each group). Four groups received scopolamine (۱mg/kg, IP) and water extract of Elaeagnus Angustifolia (۵۰, ۱۰۰, ۲۰۰ and ۴۰۰ mg/kg) along with a positive control group (received scopolamine) and a negative control group. Water extract of Elaeagnus Angustifolia was administered through gavage every day for ۴ weeks. Using Morris water maze (MWM), spatial learning and memory were evaluated. Results: The present study showed that Scopolamine injection leads to impairment of learning and memory of rats in the Morris water test (P<۰.۰۰۰۱). In addition, Elaeagnus Angustifolia water extracts dose-dependently improved the learning and memory impairment induced by scopolamine in rats (P<۰.۰۰۰۱). There was no significant difference between groups that received water extract of Elaeagnus Angustifolia and negative control group (P=۱). Conclusion: Water extract of Elaeagnus Angustifolia improves spatial learning and memory induced by scopolamine in rats. References ۱- Hampel H, Prvulovic D, Teipel S, et al. The future of Alzheimerchr('۳۹')s disease: the next ۱۰ years. Prog Neurobiol. ۲۰۱۱ ۹۵(۴): ۷۱۸-۲۸. ۲- Selkoe DJ. Alzheimerchr('۳۹')s disease: genes, proteins, and therapy. Physiol Rev. ۲۰۰۱ ۸۱(۲): ۷۴۱-۶۶. ۳- Vassar R, Bennett BD, Babu-Khan S, et al. β-Secretase cleavage of Alzheimerchr('۳۹')s amyloid precursor protein by the transmembrane aspartic protease BACE. 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Keywords:

Keywords: Elaeagnus angustifolia , Memory , Scopolamine , Morris water maze , Rats