Association of IGF۲R۳′UTR(C>A) Polymorphism in M۶P/IGF۲ Receptor Gene with Insulin Resistance Indices in Diabetic Type ۲ Patients and Non Diabetic Population

Background and objective: Association of ۶q loci, where IGF۲R gene is located, with insulin resistance has been well established. In this study, relationship between ۳chr('۳۹')UTR and type ۲ diabetes and insulin resistance indices in non diabetic subjects was investigated. Materials and Methods: ۳۵۰ participants (۱۷۵ diabetic type ۲ patient and ۱۷۵ non-diabetic individuals) were entered in this study. Demographic data were collected. BMI and serum levels of glucose, lipid profiles and IGF۲ of all participants were measured. Genotype polymorphism of studied participants was determined by PCR-RFLP method. Then, the relationship between genotypes and insulin resistance indices was measured and analyzed using statistical procedures of ANOVA and post hoc analysis. Results: The genotypes frequency comprised CC (۶.۸۵%), AA (۳۳.۴۵%), and CA (۵۹.۵۵%), indicating that the frequency of carrier with CA genotype polymorphism was significantly (P<۰.۰۵) higher in type ۲ diabetic patients (۸۰.۶%) than in non-diabetic participants. Serum FBS levels of CA carriers were significantly (P=۰.۰۰۱) higher than carriers of other two genotypes (CC and AA). The mean levels of serum IGF۲ in participants carrying CC and CA genotypes were significantly (P= ۰.۰۰۱) more than other participants carrying genotype AA. Conclusion: (C>A) IGF۲R۳′UTR polymorphism was associated with type ۲ diabetes and some insulin resistance indices especially FBS. However, the A allele may have a protective effect on developing type ۲ diabetes. References ۱- Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for ۲۰۱۰ and ۲۰۳۰. Diabetes Res Clin Pract. ۲۰۱۰ ۸۷: ۴-۱۴. ۲- Pettitt DJ, Talton J, Dabelea D, et al. 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Keywords:

Keywords: IGF۲R , Type ۲ diabetes , Polymorphism