Assessment of the protective effect of vitamin E on the quality of spermatogenesis and sperm parameters in rats exposed to lead
Publish place: Future Natural Products، Vol: 3، Issue: 2
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JHPH-3-2_002
تاریخ نمایه سازی: 12 خرداد 1400
Abstract:
Background and aims: Vitamins are a rich source of antioxidants that can neutralize the harmful effects of lead on spermatogenesis and sperm parameters. The aim of this study was to determine the effects of vitamin E on spermatogenesis and sperm parameters in lead-exposed rats. Methods: This is an experimental study on ۴۵ male Wistar that were allocated to ۵ groups: distilled water gavage, intraperitoneal distilled water, vitamin E, lead, and lead+ vitamin E. All the rats were exposed to lead for ۳۰ days. Then, the rats were sacrificed and sperm count, motility and morphology of sperm chromatin, and epididymitis and testis weight were investigated. Results: The findings showed significant differences in weight gain, epididymitis weight, sperm death, the highest mobility of sperm among the groups (P>۰.۰۵). Vitamin E and control (gavage) rats experienced more weight than other groups. There was a significant difference in the highest mobility of sperm between peritoneal control group and other groups (P<۰.۰۰۱), and in lower than ۵۰% mobility between lead group and other groups (P>۰.۰۵). There was a significant difference in sperm death between lead group, and the control groups and vitamin E group (P>۰.۰۵) with the least sperm death. Vitamin E group had a significantly lower sperm death than other groups. There was no significant difference in the testis weight, normal morphology, and normal DNA among the groups (P<۰.۰۵). Vitamin E had noticeable effects on gaining weight, epididymitis weight, and survived sperm, and a noticeable reducing effect on lead's harmful side effects on the sperm. Conclusions: The results indicate the protective effects of vitamin E on spermatogenesis quality and some sperm parameters in rats exposed to lead.
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Authors
narjeskhaton dadkhah
Nursing and Midwifery Dept., Shahrekord University of Medical Sciences, Shahrekord, I.R. Iran
mahnaz shahnazi
Nursing and Midwifery Dept., Tabriz University of Medical Sciences, Tabriz, I.R. Iran
mehran mesgari abbasi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
shahram etemadifar
Faculty Member of Nursing and Midwifery Department Shahrekord University of Medical Science, shahrekord, Iran
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