The effects of Asian Red Ginseng ethanolic extract on serum concentration of leptin hormone in male wistar rat

Background and aims: Leptin is a hormone known to control appetite and body weight. The leptin Levels in obese animals are always more than animals with normal size. A wide variety of methods have been offered to treat obesity of which herbal therapy is considered as one of these methods. The aim of this study was to investigate the effect of ethanolic extract of Asian Red Ginseng on leptin serum level in male wistar rats. Methods: In this “in vitro” experimental study, ۳۰ adult male wistar rats were randomly divided into ۵ groups equally: control (no drug), SHAM (received ۱ml of physiology serrum), Interventional group ۱ (received ۲۰mg/kg ethanolic extract of Asian red ginseng), Interventional group ۲ (received ۴۰mg/kg) and Interventional group ۳ (receiver ۸۰mg/kg). The extract was injected intraperitoneally for ۲۰ days. On the twentieth day, blood samples were collected. Dataset of experiments were collected and analyzed with Graphpad Prism ۵ software. Data were analyzed using one-way ANOVA and PResults: The dose-dependent injection of the ethanolic extract of Asain Red Ginseng root did not show a significant effect on leptin hormone serum level, but it showed a significant decrease in food intake compared to the control group. Conclusion: The ethanolic extract of Asian red ginseng root does not reduce the serum level of leptin hormone.

Keywords:

Ginseng , Male Rat , Leptin