Evaluation of Cytokeratin ۷ Expression in Different Mammary Gland Neoplasms
Publish place: Iranian Journal of Veterinary Medicine، Vol: 15، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVM-15-1_006
تاریخ نمایه سازی: 12 خرداد 1400
Abstract:
BACKGROUND: Cytokeratins are non-contractile intermediate filaments engaged in anchoring and structural functions forming a network to support cytoplasm. Cytokeratin ۷ (CK۷) expression in human breast carcinomas has proved to be a useful differentiation marker, but its expression in canine mammary gland tumors is poorly understood. OBJECTIVES: Cytokeratin ۷ (CK۷) expression in human breast carcinomas has proved to be a useful differentiation marker, but its expression in canine mammary gland tumors is poorly understood. METHODS: This research was based on the immunohistochemical study of CK۷ in ۱۷ cases of canine mammary gland neoplasms obtained from the Department of Pathology, Faculty of Veterinary Medicine, University of Tehran. Masson’s trichrome staining was performed to differentiate between collagen fibers and smooth muscle. RESULTS: CK۷ protein was detected in both epithelial (۱ benign mixed tumor, ۱ fibroadenoma, ۱ complex carcinoma, and ۱ carcinoma mixed type) and myoepithelial (۱ fibroadenoma, ۱ benign mixed tumor, ۳ complex carcinomas, ۱ ductal carcinoma, and ۱ carcinoma mixed type) cells. Fine and thick collagen fibers were observed in the sections stained by Masson’s trichrome. CONCLUSIONS: Despite using CK۷ as a differentiation marker in human breast cancer, CK۷ had a controversial ex-pression in the epithelial and myoepithelial cells in canine mammary gland neoplasms. Based on the results, CK۷ could not be considered as an independent marker for the canine mammary glands epithelial cell detection and a prognostic factor in canine mammary gland neoplasms
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Authors
Elnaz Elahirad
Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Farhang Sasani
Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Alireza Khosravi
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Mohammad Javad Gharagozlou
Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Fateme Khanbarari
Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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