The Relationship Between Polymorphic Fibroblast Growth Factor Receptor (FGFR) Gene and Breast Cancer Risk

Background: Genetic factors associated with cancer have been widelyinvestigated and several polymorphisms have been connected with breast cancer.Breast cancer (BC) can be considered one of the most popular reasons of deathamong women. BC, likewise, is the second cause of death in Iran. The presentresearch aims at determining the frequency of the fibroblast growth factor receptor(FGFR) gene polymorphism in patients with breast cancer.Methods: The FGFR family is one of the tyrosine kinase receptors containing4 members, whose pathway is activated in many tumors. We assessed, for thefirst time, these polymorphisms and their consequences on the breast cancer riskassociation in an Iranian sporadic population-based case-control study including126 patients with breast cancer and 160 controls using a PCR-RFLP-based assay.Results: The analyses of the experimental and control groups indicated thathomozygote genotype FGFR4 Gly/Gly has the highest frequency in experimentaland control groups (30.4% and 18.9%). The main genotype FGFR4 Gly/Glyrisk factors in our population were: ArgGly /GlyGly, OR = 2.359, 95% CI =0.208 - 4.621, P = 0.001; ArgArg /ArgGly, OR = 0.412, 95% CI = 0.082 - 0.547, P =0.078, ArgArg /GlyGly, OR = 0.076, 95% CI = 0.030 - 0.189, P = 0.26.Conclusions: A significant association was observed between breast cancerrisk and FGFR4 GlyGly and ArgGly polymorphism.

The Relationship Between Polymorphic Fibroblast Growth Factor Receptor (FGFR) Gene and Breast Cancer Risk Keywords:

BstNI , PCR-RFLP , FGFR4 gene , polymorphism , breast cancer