Characterization the Dynamic Mechanism of Spike-Wave Discharges in WAG/Rij Model of Absence Epilepsy

Absence epilepsy is a form of generalized seizures with Spike wave discharge in EEG. In this study, it has been tried to explore whether EEG changes can effectively detect epilepsy in animal model applying non-linear features. To predict the occurrence of absence epilepsy, a long-term EEG signal has been recorded from frontal cortex in seven Wag/Rij rats. After preprocessing, the data was transferred to the phase space to extract the brain system dynamic and geometric properties of this space. The results indicate that the brain system dynamic changes during the transition from free-seizure to pre-seizure and then seizure. Proposed approach diagnostic characteristics yielded ۹۷%accuracy of absence epilepsy diagnosis.

Keywords:

WAG/Rij , electrocorticography , animal model , absence epilepsy.