Controlled release of anticancer drugs via the magnetic magnesium iron nanoparticles modified by graphene oxide and polyvinyl alcohol: Paclitaxel and docetaxel
Publish place: Nanomedicine Journal، Vol: 8، Issue: 3
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 272
This Paper With 11 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_NAMJ-8-3_005
تاریخ نمایه سازی: 19 تیر 1400
Abstract:
Objective(s): Paclitaxel (PTX) and docetaxel (DTX) belong to the family of taxanes drugs which have been employed for treatment of ovarian, breast, lung, head, neck, gastric, pancreatic, bladder, prostate and cervical cancer. Controlled drug release systems improve the effectiveness of drug therapy by modifying the release profile, biodistribution, stability and solubility, bioavailability of drugs and minimize the side effects of anticancer drugs. So, the purpose of the present study was to synthesize the modified nanocomposite for the controlled releases of these drugs.Materials and Methods: Magnetic magnesium iron oxide nanoparticles were synthesized via the co-precipitation chemical method and then composited with graphene oxide and modified by polyvinyl alcohol. The physicochemical characterization of the prepared nanocomposites was investigated by scanning electron microscope (SEM), X-ray powder diffraction (XRD) , Fourier-transform infrared spectroscopy and vibrating-sample magnetometer.Results: Specific characteristics such as adsorption capacity, monodispersity, stability and hydrophilicity of magnetic nanomaterials were studied in the controlled release of anticancer drugs. Drug loading content and drug loading efficiency and release rate of drugs were investigated in vitro at different pH with ultraviolet-visible spectroscopy (UV-Vis). DLE and DLC of PTX and DTX in the modified magnetic nanocomposites were calculated as ۸۵.۲ ± ۲.۷% and ۷.۷۴ ± ۰.۲۴% , ۸۹.۴ ± ۱.۲% and ۸.۱۲ ± ۰.۱۱% of, respectively. The cumulative release amount of PTX and DTX from magnetic modified nanocomposites at pHs ۵.۸, ۷.۴ over ۱۰۰ h were ۵۸ % and ۴۰ % and ۵۴ % and ۳۷ %, respectively.Conclusion: The potential of modified nanocomposite in drug delivery systems from the intrinsic properties of the magnetic core combined with their drug loading capability and the biomedical properties of modified nanocomposite generated by different surface coatings. The generally sustained and controlled release profile of DTX (or PTX) facilitates the application of modified nanocomposite for the delivery of anticancer drugs.
Keywords:
Anticancer drugs , Controlled drug release , Docetaxel , Graphene oxide , Magnetic magnesium iron nanoparticles , Polyvinyl alcohol , Paclitaxel
Authors
Ahmad Gholami
Electroanalytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz ۵۳۷۱۴-۱۶۱, Iran
Biuck Habibi
Electroanalytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz ۵۳۷۱۴-۱۶۱, Iran
Amir Abbas Matin
Chromatogrphy Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz ۵۳۷۱۴-۱۶۱, Iran
Naser Samadi
Analytical Spectroscopy Research Laboratory, Department of Chemistry, Faculty of Science, Urmia University, ۱۱۷۷, Urmia, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :