Burden of Alzheimer's disease and other dementias in elderly people in Asia: a systematic analysis for the Global Burden of Disease Study in 2019 abstract
Background and Objective: Alzheimer's disease (AD) is a progressive and damaging brain disease of unknown etiology. The goal of this study is to investigate the burden of AD in Asia in 2019.Materials and Methods: All data sources accessible from the 2019 Global Burden of Disease study were used to estimate prevalence, mortality and disability-adjusted life years of the Alzheimer's disease and other dementias as well as Alzheimer's disease’s attributable risk factors in Asia from 1990 to 2019. We estimated all-cause and cause-specific mortality, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs) and attributable risks. All estimates were presented as counts and age-standardized rates per 100,000 population with uncertainty intervals (UIs).Findings: The highest incidence, prevalence, mortality, burden of disease, YLL and YLD belonged to high-income areas and the lowest to middle-income areas. There is a positive and significant correlation between human development index (HDI) and disease incidence (r = 0.319, P<0.05) and the prevalence of the disease (r=0.325, P <0.05). The results revealed a positive and significant correlation between HDI and disease burden (DALY) in women (r = 0.325, P <0.05). There is also a positive and significant correlation between HDI and YLD in both sexes (r = 0.414, P <0.05). However, no positive and significant correlation was found between HDI and YLL (P> 0.05). There incidence of AD in the elderly was positively and significantly related to the mean years of schooling (r = 0.428, P <0.05). Also, life expectancy at birth was positively and significantly correlated with the burden of disease (DALY) (r = 0.362, P <0.05) and YLL (r = 0.317, P <0.05). The results also illustrated a positive and significant correlation between YLD and mean years of schooling (r = 0.510, P <0.05) life expectancy at birth (r = 0.397, P <0.05) and expected years of schooling (r = 0.399, P <0.05).Conclusion: These estimates can be used to guide the elderly care planning and interventions. Hence, policymakers and health care providers need to be informed of these trends to provide appropriate services.