Protective Effects of Withania somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RBMB-3-2_003
تاریخ نمایه سازی: 10 شهریور 1400
Abstract:
Background: We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-۶ (IL-۶) in fructose-fed rats.
Methods: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=۱۲); Group I as control, Group II as sham-treated with WS by ۶۲.۵mg/g per diet, Group III fructose-fed rats received ۱۰%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-۶, and TNF-α levels in sera.
Results: Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-۶, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < ۰.۰۵) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-۶, and TNF-α.
Conclusion: Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.
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Authors
Zahra Samadi Noshahr
Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran
Mohammad Reza Shahraki
Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran
Hassan Ahmadvand
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran
Davood Nourabadi
Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
Alireza Nakhaei
Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran