Occult Hepatitis B Demonstrated by Anti-HBc and HBV DNA in HIV-Positive Patients
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RBMB-3-1_006
تاریخ نمایه سازی: 10 شهریور 1400
Abstract:
Background: In patients who are hepatitis B virus (HBV) DNA-positive, but HBV surface antigen (HBsAg) -negative, the infection is referred to as occult hepatitis B infection (OBI). Occult HBV infection is harmful when other liver diseases are present, and can aggravate liver damage in in patients with chronic liver diseases. In human immunodeficiency virus (HIV) infection the suppression of viral replication by the immune system might be inactivated, and classical HBV infection in OBI patients may occur. Health care professionals should be aware of OBI in HIV patients. The routine test for HBV infection in Iran is the enzyme-linked immunosorbent assay for the HBV surface antigen (ELISA HBsAg); therefore, the aim of this study was to evaluate the prevalence of OBI in Iranian HIV patients.
Methods: This cross-sectional study was conducted in ۲۰۱۲ on sera from all the known and accessible HIV patients in Jahrom and Fassa, two cities in southern Iran. All samples were tested for the HBsAg, HBV core antibody (HBcAb). All the results were analyzed using SPSS.
Results: Of the ۹۱ patients, seven (۷.۷%) were HBsAg-positive and forty-five (۴۹.۵%) were HBcAb-positive. In patients with negative HBsAg (۸۴ patients), ۳۹ (۴۶.۴%) were HBcAb positive and ۵۳ (۶۳%) were positive for HBV DNA.
Conclusion: The prevalence of HBV infection is relatively high in HIV patients, and more accurate tests than those presently in use should be used for diagnosis.
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Authors
Arezoo Honarmand
Microbiology Department, Islamic Azad University of Jahrom, Jahrom, Iran
Morteza Pourahmad
Internal Medicine Department, Jahrom University of Medical Sciences, Jahrom, Iran
Kavous Solhjoo
Microbiology Department, Jahrom University of Medical Sciences, Jahrom, Iran
Mahmoud Kohan
Nursery Department, Alborz University of Medical Sciences
Mohamad Hassan Davami
Microbiology Department, Jahrom University of Medical Sciences, Jahrom, Iran
Seyed Kamyar Mostafavi Zadeh
Infectious disease Department, Isfahan University of Medical Sciences, Isfahan, Iran