Evaluation of Antibiotic Susceptibility Pattern of Uropathogenic Escherichia coli Isolates obtained from Patients with Urinary Catheter in North of Iran

Background and Aim : Antibiotic resistance in Uropathogenic Escherichia coli (UPEC) isolates, especially in hospitalized patients with nosocomial infections such as urinary catheters, is a growing problem and challenge. Resistance genes exist for all known antibiotics in use today, and extremely resistant pathogens are becoming more common. E. coli bacteria have developed the broadest spectrum of resistance due to multiple structural adaptations and antibiotic degradation enzymes. Therefore, the aim of this study was to investigate the pattern of antibiotic resistance of UPEC isolates obtained from patients with urinary catheter in North of Iran.Methods : In this cross sectional study, ۶۰ UPEC isolates were collected from urine samples taken from patients admitted to a teaching hospital from May ۲۰۲۱ to August ۲۰۲۱ in Babol, North of Iran. After confirmation of UPEC isolates using standard microbiology tests, the disk diffusion method was used to determine antibiotic susceptibility pattern. Results : According to susceptibility test, UPEC strains was most resistant against followed by ceftriaxone (۸۰%), trimethoprim-sulfamethoxazole (۷۲%), amikacin (۶۵%), cefotaxime (۶۰%), nalidixin acide (۵۹%), gentamicin (۵۵%), nitrofurantoin (۵۱%), imipenem (۵۰%), ciprofloxacin (۴۰%). Moreover, all isolates were MDR.Conclusion : The risk of urinary tract infection increases with increasing duration of catheterization. So for avoiding to the increasing resistance of antibiotics, infection control or antibiotic administration should be done with more caution and laboratory confirmation

Keywords:

E. coli , urinary catheter , carbapenem resistance