Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 13، Issue: 3
Publish Year: 1389
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-13-3_008
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. Materials and Methods For evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. Results The extract of T. chamaedrys (۵۰-۲۰۰ mg/kg) and acetylsalicylic acid (۱۰۰ mg/kg) produced a significant (P< ۰.۰۱) inhibition of the second phase response in the formalin pain model, while only the high dose (۲۰۰ mg/kg) of the extract showed an analgesic effect in the first phase. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. The tail flick latency was dose dependently enhanced by the extract but this was significantly (P< ۰.۰۵) lower than that produced by morphine (۱۰ mg/kg). The extract (۲۵-۲۵۰ mg/kg) administered ۱ hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. No effect was observed with the dextran-induced oedema model. Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract. Conclusion The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies.
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Authors
Ali Pourmotabbed
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Amir Farshchi
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Golbarg Ghiasi
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Peyman Malek Khatabi
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
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