The Effects of Supplemental Zinc and Honey on Wound Healing in Rats

Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-14-4_012

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s) Clinicians have long been searching for ways to obtain "super normal" wound healing. Zinc supplementation improves the healing of open wounds. Honey can improve the wound healing with its antibacterial properties. Giving supplemental zinc to normal rats can increase the wound tensile strength. This work is to study the concurrent effects of zinc and honey in wound healing of normal rats. Materials and Methods One hundred and seventy two young rats were randomly divided into four groups: control, zinc-supplement, applied honey, zinc-supplement and applied honey. Two areas of skin about ۴ cm۲ were excised. The wound area was measured every ۲ days. After ۳ weeks, all animals were killed and tensile strength of wounds, zinc concentration of blood and histological improvement of wounds were evaluated. The results were analyzed using two-way ANOVA and the mean differences were tested. Results It was found that honey could inhibit the bacterial growth in skin excisions. The tensile strength was increased significantly in the second to fourth groups at ۲۱st day (P< ۰.۰۰۱). Also there was a significant increase in tensile strength at the same time in the fourth group. The results of the histological study showed a considerable increase in the collagen fibers, re-epithelialization and re-vascularization in the second to fourth groups. Conclusion The results of the present study indicate that zinc sulfate could retard re-epithelialization, but when used with natural honey (administered topically) it could have influent wound healing in non-zinc-deficient subjects as well.

Authors

Ghasem Sazegar

Department of Anatomical Sciences and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Reza Attarzadeh Hosseini

Ferdowsi University of Mashhad, Iran

Effat Behravan

Medical Toxicology Research Center, School of Pharmacy, Mashha, University of Medical Sciences, Mashhad, Iran

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  • ۱.Storm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H., Topical silver ...
  • ۲.O’Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review ...
  • ۳.O'Meara, S, Ovington, L. Antibiotics and antiseptics for venous leg ...
  • ۴.Roberts PR, Black KW, Santamauro JT, Zaloga GP. Dietary peptides ...
  • ۵.Hema SD, Shankar KM, Bhushan P. Wound healing activity of ...
  • ۶.Govindarajan R, Madhavan V, Rao CV, Shirwaikar A, Mehrotra S, ...
  • ۷.Rozaini MZ, Zuki ABZ, Noordin M, Norimah Y, Hakim AN. ...
  • ۸.Alvarez OM, Gilbreath RL. Effect of dietary thiamine on intermolecular ...
  • ۹.Aprahamian M, Dentinger A, Stock-Damge C, Kouassi JC, Grenier JF. ...
  • ۱۰.Vaxman F, Olender S, Lambert A, Nisand G, Aprahamian M, ...
  • ۱۱.Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, ...
  • ۱۲.Levine M. New concepts in the biology and biochemistry of ...
  • ۱۳.Ringsdorf WM Jr, Cheraskin E. Vitamin C and human wound ...
  • ۱۴.Hunt TK. Vitamin A and wound healing. J Am Acad ...
  • ۱۵.Sobol SE, Keswani S, Parvadia JK, Crombleholme T, Potsic WP. ...
  • ۱۶.Ehrlich HP, Hunt TK. Effect of cortisone and vitamin A ...
  • ۱۷.MacKay DJ, Miller AL. Nutritional support for wound healing. Altern ...
  • ۱۹.Tenaud I, Sainte-Marie I, Jumbou O, Litoux P, Dreno B. ...
  • ۲۰.Pereira CE, Felcman J. Correlation between five minerals and the ...
  • ۲۱.Carlisle EM. Silicon as an essential trace element in animal ...
  • ۲۲.Jiang Y, Ding G, Lu S. Behavior of dermal fibroblasts ...
  • ۲۳.Forer B, Vasilyev T, Brosh T. Dural defect repair with ...
  • ۲۴.Sandstead HH. Understanding zinc: Recent observations and interpretations. J Lab ...
  • ۲۵.Liszewski RF. The effect of zinc on wound healing: a ...
  • ۲۶.Lansdown ABG. Zinc in the healing wound. Lancet ۱۹۹۶; ۳۴۷:۷۰۶-۷۰۷ ...
  • ۲۷.Agren MS. Zinc in wound repair. Arch Dermatol ۱۹۹۹; ۱۳۵:۱۲۷۳-۱۲۳۴ ...
  • ۲۸.Ebrahimi A, Hoseini A, Sazegar G. The Effects of zinc ...
  • ۲۹.Agren MS. Studies on zinc in wound healing. Acta Derm ...
  • ۳۰.Greenway SE, Filler LE, Greenway FL.Topical insulin in wound healing: ...
  • ۳۱.Sesta G, Persanooddo L, Nisi F, Ricci L. Effects of ...
  • ۳۲.Molan PC. The evidence supporting the use honey as a ...
  • ۳۳.Subrahmanyam M. Topical application of honey in treatment of burns. ...
  • ۳۴.Subrahmanyam M. Honey impregnated gauze versus polyurethane film (op site ...
  • ۳۵.Bergman A, Yanai J, Weiss J, Bell D, David MP. ...
  • ۳۶.Yilmaz N, Nisbet O, Nisbet C, Ceylan G, Ho§gor F, ...
  • ۳۷.Cooper RA, Molan PC, Harding KG. Antibacterial activity of honey ...
  • ۳۸.Tan HT, Rahman RA, Gan SH, Halim AS, Hassan SA, ...
  • ۴۰.Fosmire GJ. Zinc toxicity. Am J Clinical Nutr ۱۹۹۰; ۵۱:۲۲۵-۲۲۷ ...
  • ۴۱.Muscara MN, McKnight W, Asfaha S, Wallace JL. Wound collagen ...
  • ۴۲.Parasad AS. Zinc: an overview. Nutrition ۱۹۹۵; II(suppl):۹۳-۹۹ ...
  • ۴۳.Levenson SM, Demetriou AA. Wound healing: biochemical and clinical aspect. ...
  • ۴۴.Agren MS, Franzen L. Influence of zinc deficiency on breaking ...
  • ۴۵.Senapati A, ThompsonPH. Zinc deficiency and the prolonged accumulation of ...
  • ۴۶.Dunford C, Cooper R, Molan P. Using honey as a ...
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