Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 18، Issue: 7
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-18-7_014
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s): A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. Materials and Methods: Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plasticizer level, curing temperature and curing time was determined on the release of diclofenac from pellets coated with polymethacrylates. Results: Increasing the plasticizer in the coating formula led to decrease in drug release and increasing the curing temperature and time resulted in higher drug release. The optimization process generated an optimum of ۳۵% drug release at ۳ hr. The level of plasticizer concentration, curing temperature and time were ۲۰% w/w, ۵۵ °C and ۲۴ hr, respectively. Conclusion: This study showed that by controllinig the physical variables optimum drug release were obtained.
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Authors
Reza Enayatifard
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Aiding Mahjoob
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Pouneh Ebrahimi
Department of Chemistry, Faculty of Basic Sciences, Golestan University, Gorgan, Iran
Pedram Ebrahimnejad
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
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