The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 15، Issue: 2
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-15-2_007
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients. Materials and Methods We determined the POLG CAG repeat length in DNA samples extracted from ۴۰ varicocele patients and ۳۰ control subjects by PCR-denature polyacrylamide gel electrophoresis and sequencing. Results The distribution of the CAG repeat length in varicocele patients showed no notable difference from that in control subjects, but we found a significant statistical inverse correlation between ۱۰/۱۰ and ۱۰/#۱۰ genotypes and varicocele grade. Conclusion These findings indicate that POLG CAG repeats may affects the varicocele grade, but the mechanisms remain to be elucidated.
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Authors
Mohammad Mehdi Heidari
Department of Biology, Science School, Yazd University, Yazd, Iran
Mehri Khatami
Department of Biology, Science School, Yazd University, Yazd, Iran
Ali Reza Talebi
Department of Anatomy, Research Clinical Center for Infertility, Shahid Sadughi University of Medical Sciences, Yazd, Iran
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