Association study of four polymorphisms in the interleukin-۷ receptor alpha gene with multiple sclerosis in Eastern Iran

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-18-6_010

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s): Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with unknown etiology. Various genetics and environmental factors contribute to the pathogenesis of the disease. The interleukin-۷ receptor alpha chain (IL-۷Ra) was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus. In this study we are trying to find the association of IL-۷Ragene polymorphisms with MS susceptibility in Eastern Iran. Materials and Methods:A case-control study was performed in two provinces Sistan & Baluchistan and Khorasan with ۲۱۹ patients and ۲۵۸ unrelated matched healthy controls, using PCR-RFLP method for four single nucleotide polymorphisms (SNPs) rs۷۷۱۸۹۱۹, rs۱۱۵۶۷۶۸۵, rs۱۱۵۶۷۶۸۶ and rs۶۸۹۷۹۳۲ of IL-۷Ra gene. Results:We found a tendency toward association with genotyping analyses in SNP rs۷۷۱۸۹۱۹ (P=۰.۰۴۸, OR=۴.۳۴۴, and ۹۵% CI=۰.۸۹۲-۲۱.۱۴۶); also genotype and allele frequency in gender and MS subtype stratification were shown to have significant association with MS. Analysis of two provinces separately showed a significant difference in results of the allele and genotype frequencies. Moreover, haplotyping analysis showed that (GTGC) has an association only in the male secondary-progressive multiple sclerosis (SPMS) patients in comparison to the healthy controls (P=۰.۰۴۳, OR=۰.۴۱۳, and ۹۵% CI=۰.۱۷۹–۰.۹۵۵). Conclusion:IL۷-Ra could be a susceptible gene to MS within the Eastern Iran population especially after MS and gender stratification.

Keywords:

Association study , Haplotype , Interleukin-۷ receptor alpha Multiple sclerosis , SNPs

Authors

Mehrdad Sadeghi Haj

Health Research Institute, Infectious and Tropical Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abbas Nikravesh

Department of Medical Biotechnology & Molecular Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Majid Pahlevan Kakhki

Department of Basic Sciences, Gonabad University of Medical Sciences, Gonabad, Iran

Nahid Rakhshi

Department of Medical Biotechnology & Molecular Sciences, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

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