ورود
مقالات فارسیISIکنفرانسهاژورنالها

Effect of Cyperus rotundus on ischemia-induced brain damage and memory dysfunction in rats

Publish place: Iranian Journal of Basic Medical Sciences، Vol: 18، Issue: 2
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
View: 147

This Paper With 6 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:
https://civilica.com/doc/1297695

شناسه ملی سند علمی:

JR_IJBMS-18-2_014

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA۱ region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment group (EECR, ۱۰۰ mg/kg/day) was gavaged from ۴ days before, to ۳ days after ischemia. Morris water maze test was performed ۱ week after ischemia for ۴ days. Brain tissue was prepared for Nissl staining. Results: Our data showed no statistical difference between the treatment and ischemia groups in water maze task. So, treatment of ischemia with EECR cannot improve spatial learning and memory. On the contrary EECR ameliorated the CA۱ pyramidal cell loss due to transient global ischemia/ reperfusion injury. Conclusion: These results suggest that EECR cannot reduce the ischemia-induced, cognitive impairments seen after transient, global cerebral ischemia but can prevent pyramidal cell loss in CA۱ region of hippocampus.

Keywords:

Cerebral ischemia , Cyperus rotundus , Morris Water Maze , Spatial Memory

Authors

Fataneh Hashem Dabaghian

Research Institute for Islamic and Complementary Medicine, Iran University of Medical Science, Tehran, Iran

Mehrdad Hashemi

Genetic Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

Maliheh Entezari

Biology Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

Shabnam Movassaghi

Anatomy Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

Seyed Ashrafadin Goushegir

Research Institute for Islamic and Complementary Medicine, Iran University of Medical Science, Tehran, Iran

Samaneh Kalantari

Biology Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

Abolfazl Movafagh

School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Zahra Nadia Sharifi

Anatomy Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Di Carlo A. Human and economic burden of stroke. Age ...
  • Sturm JW, Donnan GA, Dewey HM, Macdonell RA, Gilligan AK, ...
  • Lagali PS, Corcoran CP, Picketts DJ. Hippocampus development and function: ...
  • Pulsinelli WA, Brierley JB, Plum F. Temporal profile of neuronal ...
  • Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, ...
  • del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang ...
  • Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev ...
  • Iadecola C, Alexander M. Cerebral ischemia and inflammation. Curr Opin ...
  • Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous ...
  • Zheng Z, Yenari MA. Post-ischemic inflammation: molecular mechanisms and therapeutic ...
  • Zhu Y, Saito K, Murakami Y, Asano M, Iwakura Y, ...
  • Kuang G, He Q, Zhang Y, Zhuang R, Xiang A, ...
  • Lipton P. Ischemic cell death in brain neurons. Physiol Rev ...
  • Sunil AG, Kesavanarayanan KS, Kalaivani P, Sathiya S, Ranju V, ...
  • Pal D, Dutta S, Sarkar A. Evaluation of CNS activities ...
  • Tona L, Kambu K, Ngimbi N, Cimanga K, Vlietinck AJ. ...
  • Jia X, Williams RM. A Diastereoselective Intermolecular Pauson-Khand Approach to ...
  • Movassaghi S, Sharifi ZN, Soleimani M, Joghataei MT, Hashemi M, ...
  • Tanabe M, Watanabe T, Ishibashi M, Hirano N, Tabuchi S, ...
  • Colbourne F, Li H, Buchan AM, Clemens JA. Continuing postischemic ...
  • Bendel O, Bueters T, von Euler M, Ögren SO, Sandin ...
  • Von Euler M, Bendel O, Bueters T, Sandin J, Von ...
  • Mergenthaler P, Dirnagl U, Meisel A. Pathophysiology of stroke: lessons ...
  • Sugawara T, Chan PH. Reactive oxygen radicals and pathogenesis of ...
  • ۲۷. Seo WG, Pae HO, Oh GS, Chai KY, Kwon TO, ...
  • Koh PO. Melatonin regulates nitric oxide synthase expression in ischemic ...
  • Zhang YB, Kan MY, Yang ZH, Ding WL, Yi J, ...
  • Kumar KH, Khanum F. Hydroalcoholic extract of Cyperus rotundus ameliorates ...
  • Seo EJ, Lee DU, Kwak JH, Lee SM, Kim YS, ...
  • Lee CH, Hwang DS, Kim HG, Oh H, Park H, ...
  • Singh N. Herbal medicine-science embraces tradition: a new insight into ...
  • Bachevalier J, Meunier M. Cerebral ischemia: are the memory deficits ...
  • Whishaw IQ, Rod MR, Auer RN. Behavioral deficits revealed by ...
    • نمایش کامل مراجع