Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 17، Issue: 6
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-17-6_011
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (۵۰ mg/kg). GSP were administered via oral gavage (۲۰۰ mg/kg) for ۴ weeks. Results: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<۰.۰۵) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<۰.۰۵). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. Conclusion: GSP have protective effects against hepatic tissue injury due to antioxidant properties.
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Authors
Esrafil Mansouri
Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medical Sciences, Jundishapur University of Medical Sciences, Ahvaz, Iran
Layasadat Khorsandi
Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medical Sciences, Jundishapur University of Medical Sciences, Ahvaz, Iran
Hassan Ali Abedi
Department of Physiology, Faculty of Medical Sciences, Jahrom University of Medical Sciences, Jahrom, Iran
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