Identification of Novel Hypoxia Response Genes in Human Glioma Cell Line A۱۷۲

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-16-5_003

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

  Objective(s): Hypoxia is a serious challenge for treatment of solid tumors. This condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (WHO) astrocytoma grade IV. Hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. Furthermore, in molecular level, hypoxia can cause induction of DNA breaks in tumor cells. Identification of mechanisms responsible for these effects can lead to designing more efficient therapeutic strategies against tumor progression which results in improvement of patient prognosis.   Materials and Methods: In order to identify more hypoxia regulated genes which may have a role in glioblastoma progression, cDNA-AFLP was optimized as a Differential display method which is able to identify and isolate transcripts with no prior sequence knowledge. Results: Using this method, the current study identified ۱۲۰ Transcription Derived Fragments (TDFs) which were completely differentially regulated in response to hypoxia. By sequence homology searching, the current study could detect ۲۲ completely differentially regulated known genes and two unknown sequence matching with two chromosome contig and four sequence matches with some Expressed Sequence Tags (ESTs). Conclusion: Further characterizing of these genes may help to achieve better understanding of hypoxia mediated phenotype change in tumor cells.

Authors

Fatemeh Baghbani

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Reza Raoofian

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Hasanzadeh Nazarabadi

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Tayebeh Hamzehloei

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Soukhtanloo

Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mansur Heidari

of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Seyed Morteza Afsharzadeh

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Sahar Shekouhi

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Fahimeh Moradi

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Ira

Abdol-Azim Sarli

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Javad Zavar-Reza

Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Majid Mojarrad

۱Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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  • Anastasiadis AG, Stisser BC, Ghafar MA, Burchardt M, Buttyan R. ...
  • Jiang J, Tang YL, Liang XH. EMT: a new vision ...
  • Osinsky S, Zavelevich M, Vaupel P. Tumor hypoxia and malignant ...
  • JM. B. Tumor hypoxia in cancer therapy. Methods Enzymol ۲۰۰۷; ...
  • Duffy JP, Eibl G, Reber HA, Hines OJ. Influence of ...
  • Hoelzinger DB, Mariani L, Weis J, Woyke T, Berens TJ, ...
  • Argyriou AA, Giannopoulou E HPK. Angiogenesis and anti-angiogenic molecularly targeted ...
  • Liao D, Johnson RS. Hypoxia: a key regulator of angiogenesis ...
  • Kalliomaki TM, McCallum G, Lunt SJ, Wells PG, Hill RP. ...
  • Zhou Y, Zhou Y, Shingu T, Feng L, Chen Z, ...
  • Zhou J, Schmid T, Schnitzer S, Brune B. Tumor hypoxia ...
  • Avni R, Cohen BM N. Hypoxic stress and cancer: imaging ...
  • Amberger-Murphy V. Hypoxia helps glioma to fight therapy. Curr Cancer ...
  • Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, ...
  • Casero RA, Pegg AE. Spermidine/spermine N۱-acetyltransferasethe turning point in polyamine ...
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  • Li Z, Wang D, Na X, Schoen SR, Messing EM, ...
  • Mao XG, Yan M, Xue XY, Zhang X, Ren HG, ...
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  • Vander Heyden AB, Naismith TV, Snapp EL, Hodzic D, Hanson ...
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  • ۳۸/. Xu X, Chua CC, Gao J, Chua KW, Wang ...
  • Kariya S, Hirano M, Furiya Y, Ueno S. Effect of ...
  • Zapala B, Staszel T, Kiec-Wilk B, Polus A, Knapp A, ...
  • Kariya S, Hirano M, Furiya Y, Sugie K, Ueno S. ...
  • Hashimoto Y, Suzuki H, Aiso S, Niikura T, Nishimoto I, ...
  • Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, ...
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