Evaluation of synthetic zeolites as oral delivery vehicle for anti-inflammatory drugs

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
View: 109

This Paper With 7 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-17-5_005

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s): In this research, zeolite X and zeolite Y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. Materials and Methods: A soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. Gravimetric methods and IR spectra of prepared formulations were used to assess drug loading efficiencies into zeolite structures. Scanning Electron Microscopy (SEM) was also utilized to determine morphologies changes in synthetic zeolites after drug loading. At the next stage, dissolution studies were used to predict the in vivo performance of prepared formulations at HCl ۰.۱ N and PBS pH ۶.۵ as simulated gastric fluid (SGF) and simulated intestine fluid (SIF), respectively. Results: Drug loadings of prepared formulations was determined between ۲۴-۲۶ % w/w. Dissolution tests at SGF were shown that zeolites could retain acidic model drugs in their porous structures and can be able to limit their release into the stomach. On the other hand, all prepared formulations completely released model drugs during ۳ hr in simulated intestine fluid. Conclusion: Obtained results indicated zeolites could potentially be able to release indomethacin and ibuprofen in a sustained and controlled manner and reduced adverse effects commonly accompanying oral administrations of NSAIDs.

Authors

Elham Khodaverdi

Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ۲ Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Reza Honarmandi

Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Mona Alibolandi

Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Roxana Rafatpanah Baygi

Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Farzin Hadizadeh

Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Gholamhossein Zohuri

Department of Chemistry, Faculty of Science, Ferdowsi University, Mashhad, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Breck DW. Zeolite Molecular Sieves: Structure, Chemistry and Use. London: ...
  • Bekkum VH, Flanigen EM, Jacobs PA, Jansen JC. Introduction to ...
  • Cavallaro G, Pierro P, Palumbo FS, Testa F, Pasqua L, ...
  • Song W, Justice RE, Jones CA, Grassian VH, Larsen SC. ...
  • Denayer JF, Souverijns W, Jacobs PA, Martens JA, Baron GV. ...
  • Velu S, Ma X, Song C. New ceria-based selective adsorbents ...
  • Matsui M, Kiyozumi Y, Yamamoto T, Mizushina Y, Mizukami F, ...
  • Asuda H, Yoshimura Y. Hydrogenation of tetralin over zeolite-supported Pd-Pt ...
  • Pavelic K, Hadzija M, Bedrica L, Pavelic J, Dikic I, ...
  • Zarkovic N, Zarkovic K, Kralj M, Borovic S, Sabolovic S, ...
  • Petushkov A, Ndiege N, Salem AK, Larsen SC. Toxicity of ...
  • Petushkov A, Intra J, Graham JB, Larsen SC, Salem AK. ...
  • Fenoglio I, Croce A, Di Renzo F, Tiozzo R, Fubini ...
  • Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy ...
  • Ahuja G, Pathak K. Porous carriers for controlled/modulated drug delivery. ...
  • Donato L, Barbaro G, Drioli E, Algieri C. Controlled release ...
  • Trewyn BG, Giri S, Slowing II, Lin VSY. Mesoporous silica ...
  • Rimoli MG, Rabaioli MR, Melisi D, Curcio A, Mondello S, ...
  • Bresinska I, Balkus KJ. Studies of Gd(III)-exchanged Y-type zeolites relevant ...
  • Li WSL ZF, Jing FY, Yang XG, Li XJ, Pei ...
  • Young SW, Qing F, Rubin D, Balkus KJ, Engel JS. ...
  • Balkus KJ, Shi JM. A study of suspending agents for ...
  • Li Y, Li H, Xiao L, Zhou L, Shentu J. ...
  • Braschi I, Blasioli S, Gigli L, Gessa CE, Alberti A. ...
  • Braschi I, Gatti G, Paul G, Gessa CE, Cossi M, ...
  • Dyer A, Morgan S, Wells P, Williams C. The use ...
  • Zhang H, Kim Y, Dutta PK. Controlled release of paraquat ...
  • Breck DW. Zeolite Molecular Sieves. Wiley-Interscience: New York: ۱۹۷۴ ...
  • Cerri G, de Gennaro M, Bonferoni MC, Carmella C. Zeolites ...
  • Manuel A, Rodrigo FP, Silvia I, Jordi A, Ibarra MR, ...
  • Dyer A, Morgan S, Welles P, Williams C. The use ...
  • Horcajada P, Márquez-Alvarez C, Rámila A, Pérez-Pariente J, Vallet-Regí M. ...
  • Uglea CV, Albu J, Va˘ta˘janu A, Croitoru M, Antoniu S, ...
  • Üner M, Gönüllü U, Yener G, Altnkurt T. A new ...
  • Moustafa YM, Khoder DM, El-Awady EE, Zaitone SA. Sildenafil citrate ...
  • Moore JW, Flanner HH. Mathematical comparison of dissolution profiles. Pharm ...
  • نمایش کامل مراجع