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Title

Immunosuppressive Effects of Human Chorionic Gonadotropin (hCG) on Mesenchymal Stromal Cells

Year: 1399
COI: JR_JCMR-11-2_006
Language: EnglishView: 47
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Authors

Sepideh sadat Hosseini - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Shadi Mehrzad - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Halimeh Hassanzadeh - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR) -Khorasan Razavi, Mashhad, Iran
Hamid Reza Bidkhori - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR) -Khorasan Razavi, Mashhad, Iran
Mahdi Mirahmadi - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR) -Khorasan Razavi, Mashhad, Iran
Madjid Momeni-Moghaddam - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Fatemeh Sadeghifar - Department of Biology, Faculty of science, Hakim Sabzevari University, Sabzevar, Iran
Moein Farshchian - Stem Cells and Regenerative Medicine Research Department, Academic Center for Education, Culture and Research (ACECR) -Khorasan Razavi, Mashhad, Iran

Abstract:

     Mesenchymal stem/stromal cells (MSCs) as one of the most important types of adult stem cells secrete a variety of immunomodulatory cytokines. However, their immunomodulatory features strongly depend on the molecular cross-talk between cells and the surrounding microenvironment. Hence, some strategies were proposed to empower their beneficial effects during cell-therapeutic procedures to avoid confusing results. Licensing the cells with chemical compounds could be considered as one of the most applicable methods for induction of anti-inflammatory status in the cells. Human chorionic gonadotropin (hCG) is a pregnancy related hormone which has been shown to be essential for the establishment of a successful pregnancy. HCG supports the implantation of fetus in the maternal endometrium, due to its immunomodulatory effects. Moreover, the regulatory role of hCG has been previously mentioned in case of some autoimmune-based diseases. In the present study, the capacity of this hormone for induction of different immune-encountered genes expression was examined in primary cultures of human adipose tissue derived mesenchymal stem cells (Ad-MSCs). In this regard, Ad-MSCs were exposed to ۱۰ IU of hCG for ۷۲ hours. Molecular studies via quantitative Real-time PCR (qRT-PCR) experiments were performed to detect gene expression modifications based on the application of SYBR Green as the fluorescent dye and in comparison to the RPLP۰ as the housekeeping gene. Results confirmed that hCG significantly upregulated TSG-۶, TGF-β۱, IL-۱β and IL-۶ expression levels comparing with the control group, while it downregulates COX-۲ expression, and had no statistically significant effects on IL-۱۰ andTDO۲. In conclusion, priming Ad-MSCs with hCG may enhance the proliferation and immunoregulatory potential of these cells, although it needs further investigations to reveal involved molecular pathways.

Keywords:

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This Paper COI Code is JR_JCMR-11-2_006. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1347319/

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Hosseini, Sepideh sadat and Mehrzad, Shadi and Hassanzadeh, Halimeh and Bidkhori, Hamid Reza and Mirahmadi, Mahdi and Momeni-Moghaddam, Madjid and Sadeghifar, Fatemeh and Farshchian, Moein,1399,Immunosuppressive Effects of Human Chorionic Gonadotropin (hCG) on Mesenchymal Stromal Cells,https://civilica.com/doc/1347319

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