Stage IE Primary Bone Lymphoma:Limb Salvage for Local Recurrence

Background:   Primary bone lymphoma or non-Hodgkin lymphoma of bone is a rare disease. There are only a few case series of stage IE of this condition in medical literature. The aim of this study is to determine the rate of survival   for stage IE after combined modality treatment, the rate of local recurrence, and the results of limb salvage in cases   of local recurrence.     Methods:   We collected data from ۶۱ patients with histologically confirmed PBL treated at the Musculoskeletal   Oncology Department of our hospital from ۲۰۰۰ to ۲۰۱۰. Retrospective evaluation included demographics, symptoms, tumor locations, outcomes of surgical treatment for local recurrence and survival rates. Results:   All patients received Combined Modality Therapy. Overall,five year survival was ۸۹% and five year disease free survival rate was ۷۸%. Local recurrence occurred in ۶ patients during follow up period, which was treated surgically     by wide excision and reconstruction. The mean follow-up for the local recurrence group was ۳۶(۲۴-۵۴) months and mortality rate in this group was ۱۷%. Conclusions:   Combined Modality Therapy for stage IE primary bone lymphomaresults in good survival rate. In case   of local recurrence, wide excision and reconstruction improves the outcomes.

Keywords:

Bone , Limb salvage , Local recurrence , Lymphoma