Evaluation of Serum Pentraxin-۳ Level in Patients with Acute Myocardial Infarction Compared with Control Group

Background & Objective: The aim of this study was to measure serum pentraxin ۳ (PTX۳) in patients with acute myocardial infarction (MI) and compare it with the control group.Methods: In this case-control study, ۶۰ patients with MI (±ST-segment elevation) were included in the case group , and those with symptoms suspicious for coronary artery disease (CAD) and with no abnormal findings in angiography and troponin I level less than ۹۹th percentile of normal population were included as a control group (N=۳۰). Serum PTX۳ and troponin I were measured.Results: In this study, ۶۰ patients including ۳۴ men and ۲۶ women were included in the case group (mean age: ۶۱.۴±۸.۸۶ years in non–ST-segment elevation myocardial infarction [NSTEMI] subgroup and mean age: ۵۷.۹±۹.۴۹ years in ST-segment elevation myocardial infarction [STEMI] subgroup), as well as ۱۳ men and ۱۷ women as the control group (mean age: ۵۵.۴۷±۱۰.۰۹ years). PTX۳ level was higher in MI cases (۱۱۲۸.۴±۱۲۰۵ pg/mL) compared to controls (۳۹۴.۵±۱۷۰.۴۰ pg/mL) (P=۰.۰۰۱). There was no relationship between ejection fraction (EF) and PTX۳ level in the MI group. The area under the ROC curve (AUC) of PTX۳ in MI was presented by ۰.۸۲۸ (AUC=۰.۸۲۸) (P>۰.۰۰۱). We defined three different cutoffs for PTX in this study, in which the cutoff ≥۴۰۰ pg/mL had the highest sensitivity (۹۲%), and the cutoff ≥۷۰۰ pg/mL had the highest specificity (۹۷%). Conclusion: According to the results of this study, PTX۳ as an inflammatory marker showed higher level in patients with MI, especially in STEMI cases. Therefore, combined evaluation of troponin I and PTX۳ levels would be associated with more accuracy in diagnosis of MI.

Keywords:

Pentraxin ۳ , Troponin I , Myocardial Ischemia , Coronary angiography