Synthesis and Biological Study of Substituted ۲”-Hydoxy, ۲”,۴”-dichloro Chalcones and Their Co(II), Cu(II) and Ni(II) Complexes for Their Antioxidant and Antimicrobial Potentials

۲-methoxy-۲-hydroxychalcone (۲M۲HC) and ۴-methoxy-۲,۴-dichlorochalcone (۴M۲۴DC) and their metal complexes were synthesized, characterised and confirmed by melting point determination, Fourier transform infrared (FT-IR), UV-Visible, ۱H-NMR, EI-MS and AAS spectroscopic techniques. Elemental analysis was carried out and found in agreement with the calculated values. Metal(II) complexes, [M(L۱-۲)۲], [where M = Ni(II), Cu(II), Co(II); L=۲-methoxy-۲-hydroxychalcone (۲M۲HC) and ۴-methoxy-۲,۴-dichlorochalcone (۴M۲۴DC)] were subsequently prepared. The biological evaluation of the synthesized chalcone derivatives and the metal complexes were carried out. The chalcones and their metal complexes were screened for antioxidant (DPPH; ۲,۲-diphenyl-۱-picrylhydrazyl and ABTS; ۲,۲-azino-bis(۳-alkylbenzothiazoline-۶-sulphonic acid) and antimicrobial activities. Overall, the ligands (chalcones) and their metal complexes demonstrated good to moderate antioxidant and antimicrobial activities.

Keywords:

Chalcones , Ligands , Metal complexes , Spectroscopic , Antioxidant , Antimicrobial